Can CBD Oil Benefit You?
For thousands of years, hemp has been cultivated for food, clothing, fiber, and fuel. It is one of the world’s oldest domesticated crops. In the early days, hemp was a vital crop in the U.S. During the 1700s. Colonial farmers grew hemp mainly for its durable fiber.
However, hemp production came to a screeching halt when the Marijuana Tax Act of 1937 was passed. Mainstream attitudes towards cannabis began to sway significantly towards the negative. Hemp became the “evil weed” because it shares the same species as marijuana, even though it does not contain its abundant THC.
Over the years, many have speculated that the real reason for the anti-cannabis campaign boiled down to the worry that hemp could become a low-cost substitute for paper pulp. American industrialist William Randolph Hearst and the DuPont family had significant investments in the timber and newspaper industries. They initiated a smear campaign to destroy the lucrative hemp market for fear that the rise of hemp would undercut their profits. Nevertheless, years later, it became known that hemp does not contain a high enough cellulose concentration to be a useful paper substitute.
Eighty long years later, hemp finally regained its legal status in the U.S. after the passage of the 2018 Farm Bill. Hemp, defined as cannabis with less than 0.3% THC, is removed from Schedule I controlled substances. Hemp-derived products are legal as long as they come from licensed hemp growers. More and more universities and hospitals have begun to study it. Americans can now use CBD legally. It can be ordered online and shipped to all 50 states.
Marijuana laws are also changing at a rapid pace across America. Even though it is still illegal on the federal level, many states have legalized marijuana. For the remaining states, some have allowed it for medical use and some recreational use.
The Human Endocannabinoid System (ECS)
Cannabinoids made by our bodies are called endocannabinoids (the prefix “endo” means within). In the 1990s, researchers made an astonishing discovery that the ECS plays a major role in our overall health.
The ECS maintains constant communication with every organ system in the body.
This communication involves messenger molecules called endocannabinoids and cannabinoid receptors on every cell that accepts them. Think of it as a “key and lock” system. The receptors are locks, and the endocannabinoids are keys that bind to these receptors and unlock them.
There are two main types of receptors within the ECS – cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2).
Researchers found more than 1,000 receptors in the body. CB1 receptors are mainly located on nerve cells in the brain and spinal cord, as well as the eye and retina. CB2 receptors are predominantly found in the immune system and the organs and tissues, such as brain, spleen, blood cells, gastrointestinal, and urinary tracts.
The body produces two types of endocannabinoids – anandamide and 2-AG. These are transported into the cells through the CB1 and CB2 receptors. As we age, the body becomes less efficient in producing anandamide and 2-AG. The proper functioning of the ECS also depends on the adequacy of omega-3 in the diet.
Many people have experienced the feel-good sensation or “high” after strenuous exercise. The lifted mood comes from the release of endorphins. Researchers now know that it is also from an increase in anandamide, which mainly targets CB1 receptors and, to a lesser extent, the CB2 receptors.
The other endocannabinoid, 2-AG, transmits signals across the brain cells and activates both CB1 and CB2 receptors. 2-AG supports brain health, immune health, as well as insulin sensitivity.
Researchers have now discovered that both endocannabinoids, anandamide, and 2-AG, have a considerable impact on a variety of functions, including appetite, energy and balance, immunity, memory, metabolism, nervous system, sleep, and stress response.
Evidence For CBD Health Benefits
The Cannabis plant contains over 100 cannabinoids. These compounds closely resemble human endocannabinoid. The main cannabinoid in hemp is CBD, and in marijuana, THC.
Unlike THC, CBD does not bind directly into our cannabinoid receptors. Nevertheless, it does stimulate the activity of both CB1 and CB2 receptors without directly tapping into them. A study by the National Institute of Health found that CBD causes the body to release more endocannabinoids, especially 2-AG. Moreover, CBD inhibits the degradation of anandamide.
Scientists are now beginning to discover many of CBD’s health benefits:
CBD has been touted for a wide variety of health interests. Still, the strongest scientific evidence is for its effectiveness in treating two rare drug-resistant childhood epilepsy conditions, namely Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS). The FDA has recently approved the first-ever CBD-derived drug Epidiolex for these conditions. In numerous studies, CBD was able to reduce the number of seizures, and in some cases, it was able to stop them altogether.
CBD may offer an option for treating different types of chronic pain: fibromyalgia, gout, HIV, multiple sclerosis, neuropathic, and rheumatoid arthritis. Studies found that applying CBD oil directly on the problem area helps to lower pain and inflammation. CBD works by impacting cannabinoid receptor activity in the body, reducing inflammation, and interacting with neurotransmitters.
Researchers also found that subjects did not build up a tolerance to CBD effects, so there was no need to increase dosage continually. Unlike some pain medications, CBD is not addictive and does not have any intoxicating effects, offering much relief for people who have chronic pain.